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For example, in the case of phosphinic pseudopeptide inhibitors, which mimic the transition state of peptide substrates, Tyr549 changes orientation upon ligand binding to interact with one of the oxygen atoms of the phosphinic group, which is equivalent to the oxygen atoms of the substrate in the transition state

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doi:10.1016/S0140-6736(23)01053-X Sanyal AJ, Kaplan LM, Frias JP, et al