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However, some observational studies have reported no such correlation, and randomized controlled trials have shown no improvement in cognitive function among older adults with or without dementia, mild cognitive impairment, or Alzheimers disease when supplemented with vitamin B12 alone or in combination with folic acid, vitamin B6, or both

These include: Vegans or strict vegetarians People whove had surgery for weight loss or stomach cancer People with pernicious anemia People older than 50 Food

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B12 deficiency can lead to nerve damage, resulting in symptoms such as numbness, tingling of the hands and feet, difficulty with coordination, and more

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this effect may be due to interference with erythrocyte maturation