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Importantly, RAGE is not specific only to AGEs

In our experiments, we also assessed the serotonin metabolite 5-HIAA

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This target-selective biosafety profile strongly correlates with the PSMA-dependent cellular internalization mechanism, demonstrating favorable safety profiles associated with ligand-guided precision while effectively circumventing off-target toxicity in nonmalignant tissues

Researchers should verify the pH against the requirements of their specific in-vitro assay buffer system using a calibrated pH meter