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Ghoshal et al 266 reported that global genetic deficiency of COX-2 in mice resulted in a significant reduction in total body weight and body fat by attenuating PPAR ligand production and adipocyte differentiation

Toxicol in Vitro 39:5257

demonstrated that KHK-C promotes fructose metabolism, leading to energy imbalance and increased oxidative stress, which in turn drives tumor cell proliferation and survival

The standard Rituximab regimen includes two infusions of 1 g 2 weeks apart (some clinicians use 375 mg/m 2 weekly infusions for 4 weeks)

What Patients Should Know Right Now The FDAs formal action takes effect April 23, 2026, with the PCAC review of these substances scheduled for July 23-24, 2026