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GAGs are a group of polysaccharide molecules, also known as mucopolysaccharides, that create the foundational structure of the extracellular matrix (ECM), together with other components such as collagen, elastin, fibronectin, and laminin Biomechanically, the layer of GAGs functions as a hydrated gel that provides cushioning and resists compressive forces

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These figures describe documented research protocols and are offered for research-use-only reference, not as medical advice

doi: 10.1111/jam.14551 90

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They must also pass through the liver where metabolism often occurs before reaching the bloodstream, which reduces their effectiveness