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Statistical analysis The experimental data were all statistically analyzed by GraphPad Prism (version 8.0.1)

Unbroken cells and cell debris were removed by centrifugation at 12,000 g for 20 min, and the membranes were collected through ultracentrifugation at 160,000 g for 1 h

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Compared with those disseminated via the lymphatic system, cells that spread through the bloodstream are dependent on the ferroptosis inhibitor GPx4