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Free Radic Biol Med 196:145155 Lindermayr C (2018) Crosstalk between reactive oxygen species and nitric oxide in plants: key role of S -nitrosoglutathione reductase

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Senescent erythrocytes are characterized by loss of surface area and volume [66], increased cell density [67], reduced deformability [68], cation loss [69], membrane desialylation [70], enzymatic dysregulation [69], oxidative stress [71], hemichrome abundance [69], elevated levels of glycated hemoglobin [72], reduced expression of phagocytosis-inhibiting CD47 [73], altered protein 4.1a/protein 4.1b ratio [74], etc

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Therefore, the activation of apoptosis by metronomic chemoendocrine therapy possibly enhances clinical outcomes compared to the endocrine therapy alone, demonstrating a unique cellular response pattern between the two treatment modalities (166)