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Though much has been understood, certain mechanisms are controversial and elusive

The water content of the rat NP tissue was reflected via the mean gray values (MGVs) on the coronal T 2 -weighted images

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In synovial fibroblasts, proinflammatory cues directly impair methylation capacity: IL-1 rapidly downregulates DNMT1 and DNMT3A/3B expression and activity, promoting demethylation and stable activation of inflammatory gene programs (116)

The activity of caspase-3 was assessed using a Caspase-3 Colorimetric Assay kit (Caspase-3 Assay Kit, Abcam, ab39401), which is based on the spectrophotometric detection of the color reporter molecule p-nitroaniline (pNA) following cleavage from the labeled substrate DEVD-pNA (caspase-3) as an index