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In UV-treated HaCaT keratinocytes, EV-QuerCar upregulated Nrf2 downstream antioxidant enzymes: GCLC (1.2-fold), GCLM (1.1-fold), and SOD1 (1.3-fold) compared to NC (Fig

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165 In AD, the epidermis of AD patients exhibits a marked deficiency in Notch receptors, leading to the upregulation of alarm TSLP, which triggers Th2-associated responses as well as TSLP and IL-31-related pruritus