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Extending from the physical and biochemical properties of the engineered NPPC-derived exosomes, we further develop an injectable hydrogel filler based on clinically-tested ECM analogs including hyaluronic acid (HA) and oxidized chondroitin sulfate (OCS) as the exosome delivery platform (HACS@CPP-miR-Exo) for post-discectomy management, which is not only well tolerated in the operation-induced NP cavity but also enables sustainable release of the engineered exosomes to mediate continuous ferroptosis reversal in NPCs (Fig

10.1016/j.biopha.2020.110104 176 XiangY.ChenX.WangW.ZhaiL.SunX.FengJ.et al (2021)

J Exp Bot 57:17591768 von der Mark C, Ivanov R, Eutebach M, Maurino VG, Bauer P, Brumbarova T, Foyer C (2021) Reactive oxygen species coordinate the transcriptional responses to iron availability in Arabidopsis

Targeting the metabolism of key nutrients via pharmacological inhibition or dietary restriction can inhibit tumor growth 7,8,9,10,11

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It occurs very rarely in cases of delayed healing and prolonged inflammation post laser resurfacing