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High expression of FDX1 promotes susceptibility to cuproptosis in HCC cells, enhances the infiltration of NK cells, Th1 cells, and macrophages, and increases sensitivity to oxaliplatin (163, 164)

Examination of the distribution of apoE among the various plasma lipoproteins has shown that apoE4 has a preference for large, triglyceride-rich VLDL particles, whereas apoE3 and apoE2 associate preferentially with the small, phospholipid-rich HDL

Methylcobalamin is often considered the better option because it is already in its active form

This was first demonstrated by finding that chemical inhibition of the neutrophil oxidative burst exhibited PPP and G6PD dependence ( ex vivo ( Figure 1B-1 ): phagocytosis, release of neutrophil extracellular traps (NETs), and degranulation accompanied by rapid production of large amounts of extracellular ROS

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