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When compared to metformin, NAC and metformin both result in significant and equal decreases in BMI, hirsutism, fasting insulin, free testosterone, and menstrual irregularity

Key molecular evidence Genetic studies have provided direct evidence for the involvement of ferroptosis in AD (47,48)

Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90

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Pruritus refers to widespread itching without a visible rash

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