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Animal studies have revealed that mild to moderate acoustic overexposure, even when causing only a temporary threshold shift (TTS), can immediately and permanently induce cochlear synaptopathycharacterized by the loss of synaptic connections between cochlear hair cells and auditory nerve fibers, without any loss of the hair cells themselves 16,17,18

2011;17:PI15

Blood 90:15351544 Divi RL, Einem TL, Leonard Fletcher SL, Shockley ME, Kuo MM, St Claire MC, Cook A, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC (2010) Progressive mitochondrial compromise in brains and livers of Primates exposed in utero to nucleoside reverse transcriptase inhibitors (NRTIs)

It showed modest results and later studies did not support a strong enough obesity-drug profile for commercial viability

specifically, this species can increase the antibody response 16 and ameliorate inflammation and immunological attacks 17

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