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1.2 Targeting autophagy for cancer therapy Autophagy, a critical mechanism for maintaining cellular balance by removing damaged organelles and protein aggregates, can also facilitate cell death (Liu et al., 2023)

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462 The most advanced application of POCs is the delivery of charge-neutral oligonucleotides, such as PNA and PMO, using CPPs

Abundance of noncircular intrahepatic hepatitis B virus DNA may reflect frequent integration into human DNA in chronically infected patients

Since microtubules play an important role in maintaining cell morphology, establishing cell polarity, and intracellular information transmission, hyperphosphorylated Tau protein could result in the loss of affinity with microtubules and lead to microtubules unstable and disintegrated, which in turn affects the transport and morphological structure of nerve cells, leading to the death of nerve cells [38, 39]

MASLD is associated with reduced microbial diversity, an overrepresentation of pro-inflammatory taxa (e.g., Escherichia, Proteobacteria, Veillonellaceae), and depletion of beneficial microbes like Akkermansia muciniphila and Faecalibacterium prausnitzii