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Combination approaches that couple GSH-triggered release with ferroptosis induction, immunotherapy, radiotherapy, or metabolic modulation represent promising strategies to overcome resistance Fig

Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)

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Egypt.Poult.Sci (2018) 38)(II):40926