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2012;120(15):e60-72

In the lysolecithin demyelination model, niacin treatment promotes phagocytosis of inhibitory myelin debris by microglia/macrophages, leading to increased numbers of oligodendrocyte progenitor cells in the lesion site and improved remyelination [8]

2.2.3 T cells T cells can be classified into a number of subtypes based on their varied roles, and these subtypes also differ in their corresponding metabolic patterns

Specifically, SIRT1, SIRT3, and SIRT5 protect the cell from ROS, and SIRT2, SIRT6, and SIRT7 modulate oxidative stress 138,139

Their findings also indicated an elevated level of HDAC2 in adenocarcinoma compared to adenoma, highlighting its role in the transition from adenoma to adenocarcinoma [8]

For instance, AI-based models have been employed to predict drought tolerance in maize by integrating epigenomic and transcriptomic datasets, demonstrating the potential of computational tools in advancing crop resilience research [134]