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Blood pressure regulation through the nitric oxide signaling pathway represents a systemic vascular effect, with hypotensive activity observed in some animal experiments at higher doses

475,480,481 The encouraging results obtained with semaglutide in patients with heart failure and a preserved ejection fraction may provide a new option for this patient population, in which additional therapy, as well as another upstream therapy for patients with a higher BMI who have indications for this condition, is urgently needed

Some cited clinical trials are small

References 1 BoltonVNHaydenCRobinsonMAbdoDPericleous-SmithA

It means the relationship between concentration and results isn't linear

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