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Extrinsic factors, such as growth factors and neurotransmitters, secreted by the stem cell niche, diffusing from the nearby vasculature or released from synaptic connections relay the environmental influence onto the progression of neurogenesis in the adult hippocampus (see Figure 1)

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Roughly 30% of participants achieved their weight loss target of 20% or more

In diabetes, BBB injury is associated with increased oxidative stress and reactive oxygen species