mechanism production of glutathione Glutathione-Related Enzymes and Proteins: A Review Team:Edinburgh/Engineering

Norenhag, J

31 GrimmT.SchferA.HggerP

Hydroxyl radicals directly target the different components of DNA such as deoxyribose sugar backbone, pyrimidine and purine bases, and result from single and double-stranded breaks in the DNA (Nita and Grzybowski, 2016)

Since these metabolic reactions occur mainly in the liver, impairment in this pathway could lead to the accumulation of excess metabolites, including byproducts of amino acid and lipid metabolism, in the liver and thereby contribute to the pathogenesis of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) 12,13

doi: 10.1016/j.jclepro.2019.04.196 38 SturmS.EngelkenJ.GruberA.VugrinecS.KrothP

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity