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Diverse Biological Activities The peptide's biological activities are remarkably diverse and include stimulation of collagen and glycosaminoglycan synthesis (critical for skin, connective tissue, and wound healing), activation of wound healing mechanisms, promotion of blood vessel formation (angiogenesis) to support tissue repair and regeneration, anti-inflammatory effects that resolve excessive inflammation while supporting beneficial healing responses, antioxidant and protective effects against oxidative damage and toxic compounds, attraction of immune and repair cells to sites of injury, remodeling of extracellular matrix through regulated metalloproteinase activity, stimulation of nerve outgrowth and regeneration, and even modulation of gene expression in patterns that reverse age-related changes and restore more youthful cellular function

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2j), and NAD + content in human plasma trended downward with increased age (Supplementary Fig

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10.1016/j.jep.2019.112426 32 HuF.YangP

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Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation

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