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Hydrogen peroxide is normally then metabolized by the mitochondrial antioxidant system, including coenzyme Q10 (CoQ10), L-carnitine, and creatine

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Preclinical studies, both in vitro (e.g., using human umbilical vein endothelial cells (HUVECs) in tube formation assays) and in vivo (e.g., chick chorio-allantoic membrane (CAM) assays or tumor xenograft models in mice), have consistently demonstrated curcumins ability to inhibit these angiogenic processes in GC

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