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Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

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Tay Sachs disease (GM2 Ganglioside) using targeted enzyme replacement therapy with alpha-hexosaminidase A or substrate inhibition of glucosylceramide synthase using imino sugars (e.g., miglustat (Zavesca marketed by Actelion) = N-butyl-deoxynojirimycin (NB-DNJ))

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For perfect results, it takes 2-3 months of treatment

Front Pharmacol 13:910292