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Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: results from a multisite study

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On the one hand, the generated reactive oxygen species attack protein sulfhydryl groups (-SH), denaturing proteins and forming disulfide bonds (-S-S-), which leads to protein aggregation

While this had no effect in the absence of insulin or IGF-1, depletion of Rictor did inhibit proliferation in IGF-1- or insulin-stimulated conditions

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Of course, from my perspective, longer is better