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Science (1979)

Fragile X syndrome is caused by mutations in FMR1 gene (which encodes fragile X mental retardation protein, FMRP) expressed in both neurones and astrocytes

Further investigation revealed that both inside and outside of melanoma cells were altered in ways unfavorable for migration and invasion when ENPP2 was reduced by RNAi: cholesterol accumulated inside the melanoma cells, and the ECM was remodeled outside of the cells

Burke A, Smyth EM, Fitzgerald GA

By introducing the direct cellular transport optimization properties of the GHR peptide variant TB-500, researchers are able to track how the regulation of globular actin (G-actin) into filamentous actin (F-actin) accelerates cellular motility, allowing defensive and structural cells to rapidly populate a wound matrix

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