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While the FDA has not approved ozone for medical treatment, many patients still pursue this alternative therapy under proper medical supervision

For example, a 2014 study by Sophie C Killer and colleagues from University of Birmingham investigated whether moderate coffee consumption causes dehydration in 50 habitual male coffee drinkers consuming 36 cups per day

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To explore this, we subjected proactive and reactive zebrafish to an acute novelty stressor and subsequently quantified changes in behavior and whole brain biomarkers of oxidative stress and antioxidants (DNA damage, total glutathione (GSH), glutathione ratio, oxygen radical absorbance capacity (ORAC), and superoxide dismutase (SOD)