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Vipadenant was investigated in an open-label, PET study and showed occupation of A2A receptors varying from 74 to 94 % in human brain regions, including the putamen, at the lowest daily dose of 2.5 mg, and reached saturation in all regions at 100 mg (Brooks et al

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Primers used for the experiment are listed in Additional file 8: Table S2

p = 0.008) (Table 4)

Remarkably, the cellular zinc transport activity of ZnT7 is crucial for regulating the localization of ERp44 within the Golgi apparatus, a specific subcellular organelle