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These latter processes indicates that the metal ion is neurotoxic, and it has been associated to neurodegenerative diseases, such as the Alzheimer Disease 2 In this rather controversial context, the goal of chelation therapy is the removal of the toxic metal ion from the human body or the attenuation of its toxicity by transforming it into less toxic compounds

Lactate is the driver of lactylation and is associated with lactylation levels (11)

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First, CPT1 siRNA was used in this experiment, and we found that treatment with 2.5 mM l-carnitine significantly decreased the cellular ROS content (Fig