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It integrates signals from diverse extracellular stimuli, including growth factors, hormones and nutrients, to coordinate critical cellular responses necessary for maintaining homeostasis (106108)

PMID 22787590

Morton et al., 1995

Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines

Oral administration of kefiran exerts a bifidogenic effect on BALB/c mice intestinal microbiota

This paper presents gene profiling data relevant to GHKs effects on stem cells function