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Description

Interestingly, hepatic ER requires both estrogen binding and nutrient-dependent stimulation for its full transcriptional activation, thus acting as a metabolic checkpoint that blocks reproductive progression when amino acid intake is insufficient [2]

10.1186/s13048-024-01344-0 82 HuangC.ZhaoS.YangY.GuoT.KeH.MiX.et al (2023)

Efficacy and safety of an investigational single-course CRISPR base-editing therapy targeting PCSK9 in nonhuman primate and mouse models

AGOmiRNA complexes for in vitro co-IP assays Plasmids expressing AGO2 variants were generated from the pcDNA3.3-3xFLAG-SUMO Eu1 -HsAGO2 plasmid (Addgene, 231372)