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However, the clinical benefit of this modality has still been limited due to several defects such as adverse events, acquired drug resistance, tumor recurrence, and lack of validated biomarkers, which impel further research on mechanisms of tumor angiogenesis, the development of multiple drugs and the combination therapy to figure out how to improve the therapeutic efficacy

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Absorbance values were recorded at 405 nm using a Sunrise plate-reader (TECAN)

de Benoist B, McLean E, Egli I, Cogswell M, eds

This mutation promoted co-activator binding even with low estrogen levels and led to disturbance in ER dependent cell growth and consecutively induced drug resistance [50]

Antonina Sidoti, orcid.org/0000-0001-6980-7548 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers