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In addition, NNMT expression is not related to grade and stage in renal clear cell carcinoma but correlates negatively with tumor size, suggesting that it may play an important role in the initial malignant conversion phase (49)

[DOI] [PubMed] [Google Scholar] Bossy-Wetzel E., Petrilli A., Knott A.B

[DOI] [PubMed] [Google Scholar] 100.Tseng, A

If Emi1 is a substrate of APC/C, this implies that Emi1 could be ubiquitinated by APC/C in early G1, and that it later accumulates as an inhibitor to inactivate APC/C and promote S-phase entry, much like Cyclin F [84]