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Specific genetic and biological patterns underlying cortical morphological alterations in vascular cognitive impairment

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doi: 10.1093/toxsci/kfr235

In parallel, HMC3 cells secrete neurotrophic and angiogenic factors, including BDNF, vascular endothelial growth factor-a (VEGF-A), and insulin-like growth factor-binding protein-1 (IGFBP-1), contributing to neurovascular cross-talk, although amyloid exposure suppresses BDNF release, linking metabolic stress to impaired neuroprotective output (218)