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doi: 10.1089/ars.2017.7115

In most situations, the main reasons for poor results are low bioavailability and poor ocular penetration of the currently available antifungal drugs to the intended site of action [44]

As the hallmark roles for TrxR are to provide reducing power for RNR and antioxidant enzymes, one might first ask whether the metazoan transition was associated with novel replication- or antioxidant-demands, which might have been better served by the new TrxR

JR: supervision, writing - review and editing, and writing - original draft

*Correspondence: Jianqun Lin [email protected] Pang [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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