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Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

A study assessing mutations and polymorphisms in patients with drug-induced cholestasis, disclosed that mutations in the ABCB11 gene was significantly more frequent in patients with drug-induced cholestasis compared to healthy controls [96]

In gsnor1-3 Arabidopsis mutants, SA-dependent gene expression in response to diminished SA accumulation was compromised, whereas enhanced activity of AtGSNOR1 increased SA-dependent gene expression 60

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To better simulate the clinical situation, a xenograft mouse model derived from PDCs with high and low expression of VRK2 was employed for further study

The study suggests that the second dose of the vaccine protected more than 90% of people from either being infected or having asymptomatic COVID-19 than around 50% of those who received only one dose