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Despite this, cyanocobalamin has been increasingly criticised in recent years, due to the following reasons: Toxicity: cyanocobalamin is often claimed to be toxic, as the cyano group form the poison cyanide

Studies have shown promising results

Contribution statement All the persons listed as authors fulfil all three criteria for authorship as per the ICMJE uniform requirements

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Proton pump inhibitors, H2 receptor antagonists, and prokinetic agents may have altered effectiveness due to tirzepatides effects on gastric function

Although we did not detect changes in Setd2 expression in the colon and stomach with reprogramming (Extended Data Fig