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All constructs express and form vesicles similar to wild type gB, except for S392C/Q532C

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Am J Physiol Endocrinol Metab 307:E326E334 Wolf I, Shahmoon S, Ben Ami M, Levy-Shraga Y, Mazor-Aronovitch K, Pinhas-Hamiel O, Yeshayahu Y, Hemi R, Kanety H, Rubinek T, Modan-Moses D (2014) Association between decreased klotho blood levels and organic growth hormone deficiency in children with growth impairment

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These may include: 5-MTHF (methylfolate) for those with MTHFR variants Methylcobalamin (B12) and P5P (vitamin B6) to support neurotransmitter synthesis (dopamine, serotonin, norepinephrine) Choline and betaine (TMG) as additional methyl donors Magnesium, which supports over 300 enzymatic reactions, including methylation Since B vitamins act as fuel for your methylation pathways, they are often needed to wake them up and give them that much-needed boost