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This article reports the discovery of the ROS wave

Andreeff, M, Zhao S, Drach D, Hegewisch-Becker S, Rees J, Liu Y, Hanania E, Krbling M, Champlin R, Deisseroth A, Drach J

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VEGF plays a pivotal role in angiogenesis, the formation of new blood vessels, which is critical for delivering oxygen and nutrients to healing tissues while eliminating metabolic waste

Likewise, overexpression of prosaposin leads to an increase in whole-cell and mitochondrial CoQ 10 content, suggesting that prosaposin and/or saposin B plays a role in regulating CoQ 10 levels [155]