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6 Multiple microbes in both the small and large intestines can convert dietary L-carnitine into GBB, but relatively few can transform GBB into TMA.13 The GBB-to-TMA conversion is much higher in omnivores than in vegans and vegetarians, likely because of differences in the gut microbiota, although this aspect of the L-carnitine-to-TMAO pathway is not fully understood

First, we evaluated the bacterial community species -diversity (defined as a difference in intragroup diversity 60 ) and found that rotenone resulted in a non-significant increased -diversity which was attenuated by inhibition of CPT1 (Supplementary Fig