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For the complex relationship between TMAO and its metabolic precursors and chronic cardiovascular disease, more rigorous experimental protocols need should be designed to eliminate the interference of different precursor metabolites

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Parrino B., Schillaci D., Carnevale I., Giovannetti E., Diana P., Cirrincione G., Cascioferro S

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Broadly speaking, this can be achieved by decreasing insulin requirement (reducing insulin resistance, reducing dietary digestible carbohydrates, increasing loss of glucose through the urine) or increasing beta cell capacity (resolving glucotoxicity and using glucagon-like peptide 1 [GLP-1] receptor agonists)

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