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For example, in human PAECs under hypoxic conditions, the levels of ROS were increased, while the levels of mitochondrial thioredoxin 2, an antioxidant protein, were reduced which could contribute to exacerbating hypoxia-induced ROS production [157]

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[] However, PGC-1 is not an ideal target because its biological activity must be regulated within a very narrow and precise range

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TUDCA has been well-tolerated in clinical research