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Quantitative prediction of cellular metabolism with constraint-based models: the COBRA toolbox

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B12 is stored in the liver for several years, so it can take anywhere from 1-5 years for a person to eventually become deficient

doi: 10.3389/fimmu.2021.799558 158 LambethJ

Practical safety measures include routine lab tests and cardiovascular assessments under qualified supervision

This negative feedback loop ensures that the cell does not produce excess NADPH, which could otherwise disrupt the delicate balance of cellular redox states