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314 However, if tissue dysfunction persists, para-inflammation may evolve into a chronic and pathological inflammatory state, which not only fails to restore homeostasis but may further exacerbate tissue damage and drive disease progression

Arginine-modifying enzymes in pulmonary fibrosis Beyond its metabolic roles, arginine is subject to post-translational modifications, such as methylation and citrullination, which significantly impact pulmonary fibrosis

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Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration (1)