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[DOI] [PubMed] [Google Scholar] 58.Johannsson G, Gibney J, Wolthers T, Leung KC, Ho KK

MK 677 is also known as Ibutamoren in the scientific community

Interestingly, the expression of IGF-I and IGF-IR is profoundly reduced in the growth plates of the Cart CaSR / mice (44), suggesting that Ca 2+ /CaSR promotes chondrocyte differentiation, at least in part, by enhancing IGF-I signaling (Figure 1)

Similarly, ablation of IGF-IR in cultured osteoclast precursors reduces the number and size of osteoclasts and their expression of RANK, c-fms, and NFATc1 (unpublished data)