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The small human clock-gene study did not provide adequate safety reporting

In that trial, to reach this goal, high NAC doses were administered to patients with the registration of gastrointestinal adverse events and a considerable variability in aqueous and plasma NAC, probably only because of its relatively low absorption and bioavailability [13]

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Surprisingly, a few animals presented with classic hindlimb weakness and paralysis akin to those observed in other models of ALS (Supplemental Video 1)

This is one of the more fascinating things researchers are exploring right now, and the early findings are genuinely surprising