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Its rationale lies in modulating immune mechanisms implicated in endometriosis pathophysiology, such as inhibition of TNF- and reduction of inflammatory activation in immune cells

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Furthermore, TMAO promotes endoplasmic reticulum stress responses within podocyte cellular compartments via IRE1 and PERK pathway activation architectures, culminating in amplified production of inflammatory cytokine arsenals and accelerated apoptotic cell death trajectories (Pan et al., 2023)

Kobusch et al., 1989)

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This bidirectional axis integrates neural, immune, endocrine, and metabolic pathways, enabling gut microbes to influence mood, cognition, and behavior