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But I told them, well yeah, if your insulin sensitivity is improved, if you're carrying less body fat

GeneReviews, NCBI Bookshelf

Serum vitamin B12 and folate levels in patients with non-alcoholic fatty liver disease

Limited human observations corroborate a favorable short-term tolerability profile, usually involving mild, transient reactions such as localized injection-site irritation or temporary gastrointestinal discomfort

Well, while they absolutely are life-changing procedures, they are not going to keep your skin healthy on their own

In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet