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In June 2011, a review of two large, randomized controlled trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial prompted the FDA to alert healthcare professionals of the potential risk of an increased incidence of high-grade prostate cancer in patients receiving finasteride or dutasteride treatment

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HMT inhibitors are also promising, and had shown beneficial effects in the memory of aging mice by targeting H3K9me3 (Snigdha et al., 2016)

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A number of studies have demonstrated the benefits of combining vitamin C and E