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Description

Haas RH et al

Notably, CAR-T cells that overexpress T-bet exhibit a Th1 phenotype, which is characterized by heightened anti-tumor activity and improved survival rates in tumor-bearing murine models

Mechanistic diversity is the point

In contrast, Th1/Th17 cells, effector memory CD8 T cells, and mucosal-associated invariant T cells (MAIT cells) are enriched in gout patients joint fluids ( Imbalance of Th1 and Th2 Excessive purines dont directly enhance XOR expression in human hepatocytes