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PMID 17149725

Acta Pharmacol Sin 45 , 16601672 (2024)

Through these mechanisms, Denmark researchers believe that Epithalon can contribute to improved cellular health, potentially slowing down the aging process and promoting longevity

ALA exits the mitochondria, and the next cytoplasmic steps involve pairwise condensation of two ALA molecules by ALA dehydratase (PBGS) to form porphobilinogen (PBG), followed by tetrapyrrole assembly: PBG deaminase (HMBS) polymerizes four PBG units to hydroxymethylbilane (HMB), and uroporphyrinogen III synthase (UROS) cyclizes HMB to uroporphyrinogen III (with asymmetric orientation of the D ring)