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57 Phase 1b trial of GSBR-1290 (590 mg) in 24 healthy volunteers over 4 weeks demonstrated no study discontinuations due to AEs

Paraffin-embedded jejunum tissues were sectioned (4 m in thickness), quickly stained with haematoxylin and eosin (HE), mounted on slides, and examined using a US Moticam 3000 photomicrography imaging system for observations and photography

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Although dedicated DU trials are needed, post-hoc analyses of cardiovascular outcome trials indicate potential benefits on limb outcomes, offering a compelling rationale for specifically studying their impact on ferroptosis in DU wounds

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TABLE 1 Demographic, clinical and pathological characteristic of the study participants